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These medications prevent the reabsorption of sodium and water in a specific part of the nephron called the distal convoluted tubule.

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However, these studies were confounded by the benefits of ACE-inhibitor therapy on the rate of disease progression.

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Turns out that diuretics (Chlorothiazide in this case) are a known factor in causing Impotence in a high percentage of males.

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Cough: Presumably due to the inhibition of the degradation of endogenous bradykinin, persistent nonproductive cough has been reported with all ACE inhibitors, almost always resolving after discontinuation of therapy.

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If BP is controlled by monotherapy with hydrochlorothiazide 25 mg daily but potassium loss is problematic, can switch to fixed-combination preparation containing lisinopril 10 mg and hydrochlorothiazide 12.

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