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I decided to start taking sibutramine to lose weight that I had gained last year. I chose this because you can use it long-term, unlike the stimulants. When I first started it I barely noticed any effects (15mg). My weight was 240lbs starting. Then, about a week in I started to notice a major reduction in appetite and was doing quite well. I was able to get down to 231lbs in 1.5 weeks. Sadly this weight loss came with major dysphoric side-effects, such as tremors, anxiety, muscle twitch, insomnia, mood swings, akathesia, etc. It felt like I was poisoned/going crazy. Therefore, I had to stop it. I wish I could have continued as the weight loss was going great. Bad reactions stopped after discontinuing the sibutramine.

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I have been taking 10mg since Nov.5 2009. I have gone from 203 - 177. I went off for two weeks this past month and I have not gained but have stayed the same. During my time off however I had times of high anxiety and irritability, especially, when starting the medication again. My blood pressure and pulse rate have been fine. I have had some constipation problems.I think my Dr. will raise my dose to 15mg at my next appointment. My goal weight is 150. I feel so much better. It has helped with mild depression as well. Good Luck.

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